Research Progress on Shenling Baizhu Powder in the Treatment of Diabetic Nephropathy

Abstract

Diabetic nephropathy (DKD) is one of the most common microvascular complications of diabetes mellitus and a major cause of end-stage renal disease (ESRD). It has the characteristics of insidious onset, progressive progression and poor prognosis, which brings a heavy burden to society and families. At present, the clinical treatment of DKD is mainly based on controlling blood glucose, blood pressure and reducing urinary protein, but it is difficult to effectively delay the progression of renal function. Shenling Baizhu Powder, a classic prescription in traditional Chinese medicine, has the effects of invigorating the spleen and replenishing qi, eliminating dampness and relieving diarrhea. It is highly consistent with the core pathogenesis of DKD such as spleen-kidney deficiency and dampness turbidity internal accumulation. In recent years, a large number of basic and clinical studies have confirmed that Shenling Baizhu Powder can effectively improve the clinical symptoms of DKD patients, reduce urinary protein, protect renal function, and has high safety. This article systematically reviews the research progress of Shenling Baizhu Powder in the treatment of DKD from the aspects of TCM pathogenesis, prescription composition and compatibility, modern pharmacology, basic research, clinical application, mechanism of action, existing problems and prospects, in order to provide reference for the clinical application and in-depth research of Shenling Baizhu Powder in the treatment of DKD.